the.com/excitotoxicity
The brain cell equivalent of a standing ovation that never stops until everyone collapses.
means A process in which nerve cells are damaged or killed by excessive stimulation from excitatory neurotransmitters, especially glutamate, overactivating their receptors.
from A 20th-century scientific coinage welding 'excite' (from Latin excitare, 'to rouse, call forth') to 'toxic' (from Latin toxicum, 'poison,' itself borrowed from Greek toxikon, the stuff smeared on arrows). Researchers studying glutamate in the brain noticed that the very signal cells use to talk to each other, in excess, floods them with calcium and essentially excites them to death — so the word simply names the paradox directly: the poison here isn't a foreign substance but overstimulation itself.
- culprit
- Too much glutamate, your main excitatory neurotransmitter
- mechanism
- Calcium floods neurons until they self-destruct
- seen in
- Stroke, seizures, traumatic brain injury
- irony
- Caused by a signal that normally helps you think