the.com/translocation
A chromosome packs its bags, moves to a new address, forgets to update its ID.
means The transfer of a segment of one chromosome to another, non-homologous chromosome (or to a different spot on the same one) — a structural rearrangement of DNA rather than a change in its content.
from Straightforward Latin carpentry: 'trans-' (across, beyond) plus 'locare' (to place, from 'locus', place), built on the model of 'location' and 'relocation'. The word did ordinary duty in English for centuries meaning simply 'a moving across' — of goods, populations, even continents in plate tectonics — before 20th-century geneticists borrowed it to name the specific chromosomal shuffle: no new letters invented, just an old moving-van word drafted into cell biology.
- definition
- segment of one chromosome swaps onto another
- balanced vs unbalanced
- no DNA lost still wreaks havoc sometimes
- cancer link
- BCR-ABL translocation causes chronic myeloid leukemia
- inheritance risk
- carriers often healthy, embryos frequently are not