the.com/smallpox

The only disease humanity has ever hunted to extinction, on purpose.

means A severe, highly contagious viral disease marked by fever and a rash that turns into fluid-filled pustules, often fatal or disfiguring, now eradicated in the wild.

from From 'small' plus 'pox,' an old plural of 'pock,' meaning a pustule or blister. The 'small' was added in the 16th century to distinguish it from the 'great pox' — syphilis — whose sores were considered larger and whose reputation was, in its own way, worse.

death toll
killed roughly 300 million people in the 20th century alone
eradicated
declared gone globally in 1980, officially
vaccine origin
cowpox pus gave us the word vaccine, from vacca, cow
last known case
a hospital cook in Somalia, 1977
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