the.com/phosphorylation

Attach a phosphate group, flip a protein's mood from off to on.

means A chemical process in which a phosphate group is bonded onto a molecule—usually a protein or sugar—changing its shape, charge, or activity, most often used by cells as an on/off switch for enzymes.

from Built from 'phosphorus,' which the chemist Hennig Brand named in the 1600s from Greek 'phosphoros'—'light-bearer,' from 'phos' (light) and 'phoros' (bearer)—because the element he isolated glowed eerily in the dark. The '-ation' suffix, from Latin, turns it into 'the act of.' So phosphorylation is literally 'the act of adding the light-bearing element's compound'—a name chemistry borrowed long after phosphorus's glow had already made it famous.

the gatekeeper
kinases add it, phosphatases rip it off
energy currency
usually spent from ATP, one phosphate at a time
cellular switchboard
controls division, metabolism, and most signaling cascades
cancer link
stuck-on kinases drive many tumors' growth
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