Researchers are uncovering how glycolysis—the cellular process that breaks down glucose—directly controls gene expression, inflammation, and disease progression. Recent studies reveal that glycolytic byproducts like pyruvate chemically modify histones to alter chromatin, while specialized phosphatases and signaling pathways toggle glycolysis on and off as a metabolic switch in bacteria and cancer cells.
·Lysine pyruvylation links glycolytic flux directly to epigenetic regulation of gene expression
·Redox-sensitive phosphatases act as metabolic switches controlling glycolysis in bacterial membranes
·Pyruvate leaves chemical marks on chromatin that reshape epigenetic landscapes
·YAP signaling drives glycolysis-fueled fibroinflammation and disrupts fibroblast identity
·Glycolytic enzyme networks in acute myeloid leukemia extend beyond the classical Warburg effect
drawn from Nature, Science | AAAS, Frontiers, American Heart Association Journals · updated 3h ago